Ketamine Injection(s) - What Is It?
Ketamine injections are a form of treatment where the medication is administered through an intramuscular (IM) injection.

Ketamine IM Injection(s)

Sublingual Ketamine

Exploring Ketamine Use for Treatment-Resistant Depression (TRD), Generalized Anxiety Disorder (GAD), and PTSD: A Comprehensive Guide
Frequently Asked Questions
Understanding Ketamine
Ketamine is listed as one of the World Health Organization’s top 10 essential medications and has been safely used in anesthesia since the 1960s, particularly in pediatric care. While FDA-approved for anesthesia, it is not yet approved for pain or depression treatments. The dosage for low-dose ketamine infusions is about 20 times lower than for anesthesia, highlighting its wide safety margin.
An infusion is a method of delivering medication, such as ketamine, directly into the bloodstream through an IV (a tube placed into a vein) over a specific period of time. For depression-related treatments, infusions typically last 40-60 minutes. For pain-related conditions, the infusion duration is usually around 2 hours.
Ketamine infusion treatments are fully legal and administered under strict clinical guidelines and oversight. While ketamine is a relatively new therapy for conditions like depression and chronic pain, research and patient outcomes have demonstrated its potential to provide significant relief.
We treat patients aged 16-17 with a referral and order from a psychiatrist for depressive syndromes. For all other conditions, we treat patients 18 and older. For any specific inquiries, please contact our office.
Anesthetic IV infusions, such as ketamine, have been shown to promote neuron growth in the brain within just one hour. Additionally, ketamine has powerful anti-inflammatory properties, which may contribute to its effectiveness in pain relief.
While the exact mechanisms are still being explored, the transformative results of ketamine infusions are evident in clinics across the U.S., offering hope and relief to many patients.
Safety and Eligibility
Common side effects of ketamine infusions include mild nausea, drowsiness, and a temporary rise in blood pressure, which typically subside within an hour. IV medications can be given to manage any discomfort, and your blood pressure and heart rate will be closely monitored throughout. Less common side effects, such as vivid dreams, mood swings, or agitation, can be addressed by adjusting the ketamine dosage if needed.
No, you should continue seeing your current providers. At Bluegrass Behavioral Health & Consulting Services, we focus on ketamine infusions and offer counseling support, but we do not replace your psychiatrist, therapist, or pain specialist. Our goal is to collaborate with your existing care team to ensure coordinated and effective treatment.

When Will Effects Show?
Many patients begin to feel improvement during the treatment itself, while others notice significant changes in mood or pain levels within hours or by the next day. For some, the full benefits may become apparent after the fourth infusion.
While you may still experience ups and downs during or after treatment, overall improvement is typically observed with continued therapy.
Ketamine Therapy Duration - How Long Does It Last
The duration of treatment varies by patient. While the first infusion may offer relief for a few days, repeated treatments are often necessary for lasting results and long-term mood maintenance. For chronic conditions, we extend remission by gradually increasing the time between infusions and incorporating additional wellness techniques. Some patients may experience relief for weeks to months, and while the effects may decrease over time, they often report improved lifestyle and coping skills.
Research shows that consecutive infusions, known as the stabilization period, are more effective in promoting brain connectivity. After this period, some patients may require maintenance or “booster” infusions based on their needs and symptoms. Treatment is personalized at Serenity Health, as each patient’s response can differ. Ketamine is a treatment, not a cure, with a success rate of approximately 80% for depression and 50% for pain relief.
Ketamine - Cost and Insurance
How much does each ketamine infusion cost?
The cost of each ketamine infusion varies based on treatment type, duration, and required resources, including medications, supplies, and medical staff care. Serenity Health offers payment plans for financial assistance.
- Mental Health Infusions: $395 per infusion
- Mental Health Boosters: $295 per infusion
- Pain Infusion (1 hour): $495 per infusion
- Pain Infusion (2 hours): $595 per infusion
- Pain Infusion (3 hours): $595 per infusion
- Pain Infusion (4 hours): $695 per infusion
For more details or to discuss payment options, please call us at (859) 432-3055.
Will my insurance cover the cost?
Ketamine is not FDA-approved for depression or chronic pain, so it is not typically covered by insurance. However, some plans may reimburse a portion of the cost. Our Patient Care Advocate can assist with insurance forms and help you navigate the reimbursement process.

What To Know Before Treatment
- What should I do to prepare for my first consultation?
To prepare for your first visit:
- Fill out our health history form online or bring a completed copy.
- If referred, provide a referral form from your provider.
- Bring or have your physician send:
- Recent lab work (within the last 6 months).
- Any relevant imaging.
- A list of your health history, diagnoses, and current medications.
Do I need to stop taking any medications before starting ketamine infusions?
Never stop medications without consulting your doctor. During your consultation, we’ll review your medications and medical history to ensure ketamine is safe for you. If adjustments are needed, we’ll coordinate with your physician.

OUR TEAM PSYCHIATRIC
Special Offer:
Pay in full for your loading dose of 6 Ketamine treatments at the discounted rate of $1500. These treatments must be used within 2 calendar months (unless special circumstances apply).
WHAT WE OFFER
Affordable help with pricing
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Ketamine
A Revolutionary Approach to Mental Health
KETAMINE
Originally developed as an anesthetic, ketamine has found new life in the field of mental health due to its rapid-acting properties and its ability to provide relief when other treatments have failed. Unlike traditional antidepressants and anxiety medications, which typically target the serotonin system, ketamine works through the glutamate system — a key pathway in mood regulation, stress response, and neural connectivity.
The therapeutic use of ketamine for mental health conditions is often referred to as ketamine-assisted therapy or ketamine infusion therapy.
Ketamine’s ability to induce rapid improvement in mood and reduce anxiety has made it a groundbreaking therapy for those who have not responded well to other medications, offering new hope for better mental health outcomes.
Ketamine
Is Ketamine Right for You?
KETAMINE
This approach has been particularly effective for patients with treatment-resistant depression (TRD), who have not found relief from conventional antidepressants, and for those suffering from PTSD and generalized anxiety disorder (GAD), where traditional treatments can sometimes be less effective or take longer to show results.
IMPORTANT: Patients who want to start Ketamine treatment must first consult with a professional.
Ketamine
Treatment-Resistant Depression (TRD)
KETAMINE
TRD refers to cases of depression that don’t respond well to conventional treatments, such as psychotherapy or medications like SSRIs (Selective Serotonin Reuptake Inhibitors). For individuals who have struggled to find relief, ketamine infusion therapy has shown significant promise. Research has shown that ketamine can produce rapid improvements in depressive symptoms, often within hours or a few days after treatment. This makes ketamine a potential breakthrough option for those who haven’t found success with traditional approaches.
Generalized Anxiety Disorder (GAD):
GAD involves excessive, persistent worry and anxiety that can interfere with daily life. Ketamine has shown potential in early studies to help reduce anxiety and alleviate symptoms in those with GAD. Though research is still ongoing, ketamine may offer an alternative option for patients whose anxiety has not improved with other treatments.
Post-Traumatic Stress Disorder (PTSD):
PTSD can cause intense distress following a traumatic event, with symptoms such as intrusive memories, emotional numbness, and heightened anxiety. Ketamine infusion therapy has shown potential in alleviating some of these symptoms. Some studies suggest that ketamine can help decrease intrusive thoughts and improve emotional processing. While the research is still in its early stages, many patients report feeling significant relief after ketamine treatments, offering hope for those who have not found success with traditional PTSD therapies.
Ketamine
Conclusion: A Promising Option in Mental Health Treatment
KETAMINE
Ketamine offers hope for those with treatment-resistant depression (TRD), generalized anxiety disorder (GAD), and post-traumatic stress disorder (PTSD) who have not found relief from traditional therapies or SSRIs. Its rapid effects and ability to address treatment resistance make it an exciting area of ongoing research. However, ketamine should be used with care, following a comprehensive evaluation of each patient’s unique health needs, as well as a careful consideration of the potential risks and benefits.
Ketamine
Ketamine vs. Traditional Therapies and SSRIs
KETAMINE
- Speed of Onset:
One of the biggest differences between ketamine and traditional treatments like SSRIs and therapy is how quickly they work. SSRIs and therapy often take weeks or even months to produce noticeable improvements in symptoms. In contrast, ketamine can lead to rapid improvements in mood and anxiety, often within hours or a few days after treatment. This makes ketamine a great option for those needing fast relief, especially during a crisis. - Efficacy:
Ketamine has shown promising results, especially for individuals with treatment-resistant depression (TRD)—those who haven’t found relief with multiple antidepressants or therapies. For many of these patients, ketamine has provided significant relief, sometimes when other options have failed. However, it’s important to note that not everyone responds the same way, and the long-term effects of repeated ketamine treatments are still being researched.
Contraindications and Side Effects
- Contraindications: Ketamine is not recommended for individuals with:
- A history of substance abuse.
- Certain medical conditions.
- Heart conditions.
- Venous malformations.
- Uncontrolled high blood pressure.
- Severe liver or kidney disease.
- A history of psychosis.
- Possible Side Effects: Some common side effects of ketamine infusion therapy include:
- Dissociation.
- Dizziness.
- Nausea.
- Increased heart rate.
Serious reactions (exceptional cases) include:
- Hallucinations.
- Confusion.
- Changes in blood pressure.
These side effects are typically temporary and are closely monitored during treatment.
- Effectiveness: Ketamine is NOT effective for everyone. Studies show that approximately 7 out of 10 individuals report positive results from ketamine therapy, but some may not experience significant benefits. It’s important to have realistic expectations and work closely with your healthcare provider to assess the best treatment plan for you.
PRICING
While Spravato, an FDA-approved nasal ketamine product, is used for TRD, other forms of ketamine treatment are typically considered off-label. As a result, insurance usually does not cover these treatments.
This means that patients often need to pay out-of-pocket for ketamine therapy treatments.
Pricing Structure for Ketamine Treatment
Ketamine Treatment Pricing Structure
Ketamine treatment for mood disorders is offered with a pricing structure designed to reflect the quality of care and the potential benefits. Below is a breakdown of the updated pricing:
Initial Loading Dose Package:
To begin ketamine treatment, an initial loading dose is recommended for optimal results. This includes 6 sessions:
First session: $400
Additional sessions: $275 each
Booster Infusions:
Booster infusions help to maintain the positive effects of ketamine. These can be scheduled based on individual preferences, typically on a monthly, quarterly, or bi-annual basis.
Each booster session: $275
Compounded Ketamine Lozenges:
Some clients opt for compounded ketamine lozenges to help manage symptoms and extend the time between booster infusions. The price depends on the dosage.
Sublingual Ketamine Option:
For patients interested in sublingual (under-the-tongue) ketamine, an in-office session will first be required for monitoring and assessing response.
Important Reminder |